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Parkinsonism Relat Disord. 2007 Aug;13(6):333-9. Epub 2007 Feb 8.

Essential tremor: phenotypic expression in a clinical cohort.

Author information

1
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32225, USA. whaley.nathaniel@mayo.edu

Abstract

OBJECTIVES:

Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria.

METHODS:

A clinical series of 487 consecutive individuals diagnosed with ET were included for study.

RESULTS:

The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET.

CONCLUSION:

The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.

[Indexed for MEDLINE]

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