Format

Send to

Choose Destination
Amino Acids. 2007;32(4):561-72. Epub 2007 Feb 7.

Mechanisms of homocysteine toxicity in humans.

Author information

1
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland. asiape1@yahoo.com

Abstract

Homocysteine, a non-protein amino acid, is an important risk factor for ischemic heart disease and stroke in humans. This review provides an overview of homocysteine influence on endothelium function as well as on protein metabolism with a special respect to posttranslational modification of protein with homocysteine thiolactone. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer. Incorporation of Hcy into protein via disulfide or amide linkages (S-homocysteinylation or N-homocysteinylation) affects protein structure and function. Protein N-homocysteinylation causes cellular toxicity and elicits autoimmune response, which may contribute to atherogenesis.

PMID:
17285228
DOI:
10.1007/s00726-006-0432-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center