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J Clin Endocrinol Metab. 2007 Apr;92(4):1263-8. Epub 2007 Feb 6.

The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies.

Author information

1
Department of Endocrinology, Azienda Ospedaliera LE/1, P.O. V. Fazzi, Piazza F. Muratore, 73100 Lecce, Italy. robnegro@tiscali.it

Abstract

CONTEXT:

Pregnant women who are positive for thyroid peroxidase antibodies [TPOAb(+)] are prone to develop postpartum thyroid dysfunction (PPTD) and permanent hypothyroidism. Selenium (Se) decreases thyroid inflammatory activity in patients with autoimmune thyroiditis.

OBJECTIVE:

We examined whether Se supplementation, during and after pregnancy, influences the thyroidal autoimmune pattern and function.

DESIGN:

This was a prospective, randomized, placebo-controlled study.

SETTING:

The study was conducted in the Department of Obstetrics and Gynecology and Department of Endocrinology.

PATIENTS:

A total of 2143 euthyroid pregnant women participated in the study; 7.9% were TPOAb(+).

INTERVENTIONS:

During pregnancy and the postpartum period, 77 TPOAb(+) women received selenomethionine 200 microg/d (group S1), 74 TPOAb(+) women received placebo (group S0), and 81 TPOAb(-) age-matched women were the control group (group C).

MAIN OUTCOME MEASURES:

We measured the prevalence of PPTD and hypothyroidism.

RESULTS:

PPTD and permanent hypothyroidism were significantly lower in group S1 compared with S0 (28.6 vs. 48.6%, P<0.01; and 11.7 vs. 20.3%, P<0.01).

CONCLUSION:

Se supplementation during pregnancy and in the postpartum period reduced thyroid inflammatory activity and the incidence of hypothyroidism.

PMID:
17284630
DOI:
10.1210/jc.2006-1821
[Indexed for MEDLINE]
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