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Hum Reprod. 2007 May;22(5):1273-8. Epub 2007 Feb 6.

Immune-related disease before and after vasectomy: an epidemiological database study.

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1
Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Oxford, UK. michael.goldacre@dphpc.ox.ac.uk

Abstract

BACKGROUND:

Vasectomy can be followed by an autoimmune-antibody response. We aimed to determine whether men with immune-related diseases were more or less likely than others to have a vasectomy and then to determine whether vasectomy is associated with the subsequent development of immune-related diseases.

METHODS:

A database of linked records of hospital statistics was analysed. By comparing a population of men who underwent vasectomy with a reference population, we calculated the rate ratios for selected immune-related diseases before and after vasectomy.

RESULTS:

Some diseases studied (e.g. asthma and diabetes mellitus) were a little less common, prior to operation, in the vasectomy group than in the reference group. Others were not different. The mean period of follow-up was 13 years. We found no long-term elevation of risk following vasectomy of asthma, diabetes mellitus, ankylosing spondylitis, thyrotoxicosis, multiple sclerosis, myasthenia gravis, inflammatory bowel disease, rheumatoid arthritis or testicular atrophy. There was a short-term elevation of risk of orchitis/epididymitis.

CONCLUSIONS:

In this large study, with many years of follow-up, we found no evidence that vasectomy increases the subsequent long-term risk of immune-related diseases.

PMID:
17284511
DOI:
10.1093/humrep/dem010
[Indexed for MEDLINE]
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