Fluoroquinolone resistance in Haemophilus influenzae is associated with hypermutability

Antimicrob Agents Chemother. 2007 Apr;51(4):1566-9. doi: 10.1128/AAC.01437-06. Epub 2007 Feb 5.

Abstract

Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P=0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Fluoroquinolones / pharmacology*
  • Genes, Bacterial / genetics
  • Haemophilus Infections / microbiology
  • Haemophilus influenzae / drug effects
  • Haemophilus influenzae / genetics*
  • Haemophilus influenzae / isolation & purification
  • Humans
  • Microbial Sensitivity Tests
  • Mutation / drug effects
  • Mutation / genetics*

Substances

  • Anti-Infective Agents
  • Fluoroquinolones