Abstract
Forty-three percent (12/28) of ciprofloxacin (CIP)-nonsusceptible respiratory isolates of Haemophilus influenzae were hypermutable, compared with 8.5% (3/35) in the CIP-susceptible control group (P=0.002). CIP-nonsusceptible mutants were obtained with hypermutable strains only; these mutants developed three resistance mechanisms in a step-by-step process: target modifications, loss of a porin protein, and increased efflux.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology
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Drug Resistance, Bacterial / genetics*
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Fluoroquinolones / pharmacology*
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Genes, Bacterial / genetics
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Haemophilus Infections / microbiology
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Haemophilus influenzae / drug effects
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Haemophilus influenzae / genetics*
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Haemophilus influenzae / isolation & purification
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Humans
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Microbial Sensitivity Tests
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Mutation / drug effects
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Mutation / genetics*
Substances
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Anti-Infective Agents
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Fluoroquinolones