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Rheumatology (Oxford). 2007 May;46(5):861-7. Epub 2007 Feb 4.

Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women.

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  • 1Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, UK. Bette.Liu@ceu.ox.ac.uk

Abstract

OBJECTIVES:

To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women.

METHODS:

In a prospective cohort study 490 532 women aged 50-69 yrs who were recruited in the UK in 1996-2001 were followed over 2.9 yrs for incident primary hip and knee replacements.

RESULTS:

Height, weight and BMI were all associated with the risk of hip and knee replacement. Comparing the tallest group (>or=170 cm) with the shortest (<155 cm) the relative risks were 1.90 (95%CI 1.55-2.32) for hip replacement and 1.55 (95%CI 1.19-2.00) for knee replacement. Comparing the heaviest group (>or=75 kg) with the lightest (<60 kg) the relative risks of hip and knee replacement were 2.37 (95%CI 2.04-2.75) and 9.71 (95%CI 7.39-12.77), respectively. Comparing obese women (BMI >or= 30 kg/m(2)) to women with a BMI < 22.5 kg/m(2), the relative risks for hip and knee replacement were 2.47 (95%CI 2.11-2.89) and 10.51 (95%CI 7.85-14.08), respectively. These effects did not vary according to age, education, alcohol and tobacco consumption, or with use of hormonal therapies. Currently, an estimated 27% of hip replacements and 69% of knee replacements in middle-aged women in the UK are attributable to obesity.

CONCLUSION:

In middle-aged women, the risk of having a hip or knee replacement increases with both increasing height and increasing BMI. From a clinical perspective, relatively small increases in average BMI among middle-aged women are likely to have a substantial impact on the already increasing rates of joint replacement in the UK.

PMID:
17282995
DOI:
10.1093/rheumatology/kel434
[PubMed - indexed for MEDLINE]
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