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Semin Immunol. 2007 Feb;19(1):41-7. Epub 2007 Feb 5.

What is the role of Toll-like receptors in bacterial infections?

Author information

1
Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany. gerold@mpiib-berlin.mpg.de

Abstract

Innate immunity relies on signalling by Toll-like receptors (TLRs) to alert the immune system of the presence of invading bacteria. TLR activation leads to the release of cytokines that allow for effective innate and adaptive immune responses. However, the contribution of different TLRs depends on the site of the infection and the pathogen. This review will describe the involvement of TLRs in the development of three different bacterial infections as well as our current understanding of the role of TLRs during microbial pathogenesis.

PMID:
17280841
DOI:
10.1016/j.smim.2006.12.003
[Indexed for MEDLINE]

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