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J Pediatr Hematol Oncol. 2007 Feb;29(2):125-7.

Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab.

Author information

1
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. mohamed-radhi@uiowa.edu

Abstract

A 4-month-old girl diagnosed with familial hemophagocytic lymphohistiocytosis underwent a matched unrelated, umbilical cord blood transplant. Six weeks later she developed severe acute autoimmune hemolytic anemia and thrombocytopenia requiring multiple transfusions. This was refractory to high-dose steroid and intravenous immunoglobulin, but did respond to Rituximab (anti-CD20 monoclonal antibody) 375 mg/m2. Hemolysis recurred after steroid tapering but responded to a second course of Rituximab. This case report highlights the difficulty in managing posttransplant autoimmune hemolytic anemia.

PMID:
17279011
DOI:
10.1097/MPH.0b013e3180320b23
[Indexed for MEDLINE]

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