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J Clin Rheumatol. 2007 Feb;13(1):38-40.

Familial Mediterranean fever successfully treated with etanercept.

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  • 1Department of Medicine, Division of Rheumatology, New York University School of Medicine/Hospital for Joint Diseases, New York, NY 10003, USA.


Colchicine is the only drug known to effectively prevent familial Mediterranean fever (FMF) attacks, as well as FMF-associated amyloidosis. Unfortunately, colchicine is neither always effective nor always well tolerated, leaving some patients and their physicians with inadequate weaponry to fight this hazardous disease. We present a patient with recurrent episodes of abdominal, scrotal, and joint attacks, who was diagnosed with FMF and advised to take colchicine. Diarrhea prevented optimal treatment with this drug and led to a trial of etanercept, with resolution of FMF manifestations. This case adds to a growing body of evidence suggesting that tumor necrosis factor (TNF) blockade may result in resolution and prevention of further FMF attacks.

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