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World J Gastroenterol. 2007 Jan 28;13(4):607-11.

Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats.

Author information

1
Department of Pharmacology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Turkey.

Abstract

AIM:

To examine the anti-ulcerogenic and antioxidant effects of aqueous extracts of Foeniculum vulgare (FVE) on ethanol-induced gastric lesions in rats.

METHODS:

FVE was administered by gavage at doses of 75, 150 and 300 mg/kg, and famotidine was used at the dose of 20 mg/kg. Following a 60 min period, all the rats were given 1 mL of ethanol (80%) by gavage. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated; whole blood malondialdehyde (MDA) and reduced glutathione (GSH), serum nitrate, nitrite, ascorbic acid, retinol and beta-carotene levels were measured in all the groups.

RESULTS:

It was found that pretreatment with FVE significantly reduced ethanol-induced gastric damage. This effect of FVE was highest and statistically significant in 300 mg/kg group compared with the control (4.18 +/- 2.81 vs 13.15 +/- 4.08, P < 0.001). Also, pretreatment with FVE significantly reduced the MDA levels, while significantly increased GSH, nitrite, nitrate, ascorbic acid, retinol and beta-carotene levels.

CONCLUSION:

FVE has clearly a protective effect against ethanol-induced gastric mucosal lesion, and this effect, at least in part, depends upon the reduction in lipid peroxidation and augmentation in the antioxidant activity.

PMID:
17278229
PMCID:
PMC4065985
DOI:
10.3748/wjg.v13.i4.607
[Indexed for MEDLINE]
Free PMC Article

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