Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Pharmacol. 2007 Apr;7(2):201-7. Epub 2007 Feb 2.

Regulators of G protein signalling: a spotlight on emerging functions in the cardiovascular system.

Author information

1
Department of Experimental and Clinical Pharmacology and Toxicology Mannheim, University of Heidelberg, Mannheim, Germany. thomas.wieland@pharmtox.uni-heidelberg.de

Abstract

Regulator of G protein signalling (RGS) proteins are GTPase-activating proteins for heterotrimeric G protein alpha subunits, and are therefore physiologically and pathophysiologically important negative regulators of G-protein-coupled receptor signalling in the cardiovascular system. Owing to the functional redundancy of many of the 20 RGS, and more than 20 RGS-like, proteins even within a single cell, animal models shedding light on the functions of individual RGS proteins are often missing. Nevertheless, RGS2 is a member of this protein family, for which specific functions in the vasculature and the heart are now emerging. Recent data show that the 519-amino acid RGS3, the only RGS protein with an additional G protein betagamma dimer binding domain, largely alters the signalling of G(i) proteins to the monomeric GTPases Rac1 and RhoA in cardiomyocytes. In addition, an alternative approach using transgenic animals expressing RGS-resistant G protein alpha subunits now highlights the contributions of RGS proteins to distinct signalling pathways in the heart.

PMID:
17276730
DOI:
10.1016/j.coph.2006.11.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center