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Biochem Biophys Res Commun. 2007 Mar 30;355(1):1-5. Epub 2007 Jan 30.

Molecular pathways of angiogenesis inhibition.

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1
Angiogenesis Laboratory, Department of Pathology, Research Institute for Growth and Development (GROW), University of Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.

Abstract

A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval of the first angiostatic agent for clinical treatment of cancer. Progress has been achieved in decrypting the cellular signaling in endothelial cells induced by angiostatic agents. These agents predominantly interfere with the molecular pathways involved in migration, proliferation and endothelial cell survival. In the current review, these pathways are discussed. A thorough understanding of the mechanism of action of angiostatic agents is required to develop efficient anti-tumor therapies.

PMID:
17276388
DOI:
10.1016/j.bbrc.2007.01.123
[Indexed for MEDLINE]
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