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J Clin Virol. 2006 Dec;37 Suppl 1:S92-6.

Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome.

Author information

1
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. tetsushi@fujita-hu.ac.jp

Abstract

BACKGROUND:

Human herpesvirus 6 (HHV-6) reactivation has been suggested to modify the clinical features of drug induced hypersensitivity syndrome (DIHS). However, mechanisms for viral reactivation and modification of the clinical features remain unclear.

OBJECTIVE:

To determine whether cytokines play an important role in viral reactivation and modification of the clinical features.

STUDY DESIGN:

We examined the kinetics of serum cytokines and viral load in HHV-6 infections of six patients with DIHS.

RESULTS:

HHV-6 infection occurred three to four weeks after the onset of disease. Elevated TNF-alpha and IL-6 levels were observed to precede HHV-6 infection in four of the six patients. Although high levels of IL-6 were observed in samples collected prior to HHV-6 infection, the amounts of this cytokine significantly decreased to undetectable levels during viral infection in five of the six patients. Subsequently, serum IL-6 levels were increased after viral infection in five patients. IL-1beta levels were also increased at the time of viral infection in three of the six patients. Neither IL-4 nor IFN-gamma could be detected in any of the samples.

CONCLUSION:

These results demonstrate that cytokines play an important role in HHV-6 reactivation in patients with DIHS.

PMID:
17276377
DOI:
10.1016/S1386-6532(06)70019-1
[Indexed for MEDLINE]

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