Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Microbiol. 2007 Mar;15(3):109-18. Epub 2007 Feb 2.

Oxylipins as developmental and host-fungal communication signals.

Author information

1
The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich, NR4 7UH, UK. dimitrios.tsitsigiannis@tsl.ac.uk

Abstract

Pathogenic microbes and their hosts have acquired complex signalling mechanisms to appraise themselves of the environmental milieu in the ongoing battle for survival. Several recent studies have implicated oxylipins as a novel class of host-microbe signalling molecules. Oxylipins represent a vast and diverse family of secondary metabolites that originate from the oxidation or further conversion of polyunsaturated fatty acids. Among the microbial oxylipins, the fungal oxylipins are best characterized and function as hormone-like signals that modulate the timing and balance between asexual and sexual spore development in addition to toxin production. Coupled with other studies that implicate a role for fungal oxylipins in pathogenesis by Aspergillus and Candida spp., these results suggest that host and microbial oxylipins might interfere with the metabolism, perception or signalling processes of each other.

PMID:
17276068
DOI:
10.1016/j.tim.2007.01.005
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center