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Exp Gerontol. 2007 May;42(5):385-90. Epub 2007 Jan 31.

Hematopoietic stem cell aging: mechanism and consequence.

Author information

1
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. drossi@stanford.edu

Abstract

Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells.

PMID:
17275237
PMCID:
PMC1892213
DOI:
10.1016/j.exger.2006.11.019
[Indexed for MEDLINE]
Free PMC Article
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