Send to

Choose Destination
See comment in PubMed Commons below
Eur Ann Allergy Clin Immunol. 2006 Dec;38(10):355-60.

Efficacy and tolerability of high dose sublingual immunotherapy in patients with rhinoconjunctivitis.

Author information

Allergie-Centrum Charité, Klinik für Dermatologie und Allergologie Universitätsmedizin Berlin, Universitätsklinikum Charité, Charite-Platz 1, D-10117 Berlin.


In a multi-centre, randomized, double-blind, placebo-controlled clinical trial over 3 years high dose sublingual specific immunotherapy with an extract of a 6-grass-pollen mixture showed a highly significant and clinically relevant improvement in patients with grass pollen rhinitis/-conjunctivitis with or without asthma and an increase in allergen specific antibodies (IgG1, IgG4) indicating immunological efficacy. A difference of 46% in mean symptom medication score between active and placebo group was seen. The treatment with the sublingual solution was well tolerated. High dose sublingual immunotherapy can therefore be considered as an efficient therapeutic option in the management of IgE-mediated allergic airway diseases.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center