Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Hum Genet. 2007 Mar;80(3):531-8. Epub 2007 Jan 22.

No gene is an island: the flip-flop phenomenon.

Author information

1
Center for Human Genetics, Duke University Medical Center, Durham, NC, USA.

Erratum in

  • Am J Hum Genet. 2007 May;80(5):1002.

Abstract

An increasing number of publications are replicating a previously reported disease-marker association but with the risk allele reversed from the previous report. Do such "flip-flop" associations confirm or refute the previous association findings? We hypothesized that these associations may indeed be confirmations but that multilocus effects and variation in interlocus correlations contribute to this flip-flop phenomenon. We used theoretical modeling to demonstrate that flip-flop associations can occur when the investigated variant is correlated, through interactive effects or linkage disequilibrium, with a causal variant at another locus, and we show how these findings could explain previous reports of flip-flop associations.

PMID:
17273975
PMCID:
PMC1821115
DOI:
10.1086/512133
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center