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Wide-range, picoampere-sensitivity multichannel VLSI potentiostat for neurotransmitter sensing.

Author information

1
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. kartik@jhu.edu

Abstract

Neurotransmitter sensing is critical in studying nervous pathways and neurological disorders. A 16-channel current-measuring VLSI potentiostat with multiple ranges from picoamperes to microamperes is presented for electrochemical detection of electroactive neurotransmitters like dopamine, nitric oxide etc. The analog-to-digital converter design employs a current-mode, first-order single-bit delta-sigma modulator architecture with a two-stage, digitally reconfigurable oversampling ratio for ranging the conversion scale. An integrated prototype is fabricated in CMOS technology, and experimentally characterized. Real-time multi-channel acquisition of dopamine concentration in vitro is performed with a microfabricated sensor array.

PMID:
17271192
DOI:
10.1109/IEMBS.2004.1404134

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