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Fertil Steril. 2007 Jun;87(6):1473-6. Epub 2007 Jan 30.

Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome.

Author information

1
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

Abstract

In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3beta (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3beta contributes to the pathophysiology and inherited basis of PCOS.

PMID:
17270183
PMCID:
PMC2012940
DOI:
10.1016/j.fertnstert.2006.11.041
[Indexed for MEDLINE]
Free PMC Article

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