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Appl Opt. 2007 Jan 10;46(2):262-72.

Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics.

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  • 1Faculty of Physics, Moscow State University, Moscow, Russia.


One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array transducer were obtained. The results of numerical modeling were compared with known analytical solutions and further validated by phantom experiments. The OA images of a 3 mm piece of bovine liver immersed in diluted milk at various depths were obtained. Based on the results of modeling, a signal filtering algorithm for OA image contrast enhancement has been proposed.

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