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Chem Soc Rev. 2007 Feb;36(2):296-313. Epub 2006 Nov 7.

Supramolecular architectures generated by self-assembly of guanosine derivatives.

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Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.


Nature's use of a simple genetic code to enable life's complex functions is an inspiration for supramolecular chemistry. DNA nucleobases carry the key information utilizing a variety of cooperative and non-covalent interactions such as hydrophobic, van der Waals, pi-pi stacking, ion-dipole and hydrogen bonding. This tutorial review describes some recent advances in the form and function provided by self-assembly of guanine (G) based systems. We attempt to make connections between the structures of the assemblies and their properties. The review begins with a brief historical context of G self-assembly in water and then describes studies on lipophilic guanosine analogs in organic solvents. The article also focuses on examples of how G analogs have been used as building blocks for functional applications in supramolecular chemistry, material science and nanotechnology.

[Indexed for MEDLINE]

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