Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2007 Feb 1;6(3):295-9. Epub 2007 Feb 28.

Control of keratinocyte proliferation and differentiation by p63.

Author information

1
Veterans Affairs, Palo Alto Healthcare System, Palo Alto, California, USA.

Abstract

The p53 family member p63 has been implicated in both the development and maintenance of stratified epithelial tissues, including the epidermis. Increasing data support p63 function in the regenerative capacity of basal keratinocytes by maintaining cell proliferation. Recent studies further suggest this regulation relies on inhibition of p53 activity. In addition, p63 appears to exert separate control over epidermal differentiation, which may involve control of such key signaling molecules as IKKalpha and Notch. While studies over the past decade have greatly expanded our knowledge of p63 function, much remains to be understood regarding how p63 regulates epidermal homeostasis. Future efforts to identify and validate direct p63 target genes as well as to understand the expression and function of individual p63 isoforms will be important to further define how p63 functions in the control of keratinocyte proliferation and differentiation.

PMID:
17264679
DOI:
10.4161/cc.6.3.3753
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center