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Org Lett. 2007 Mar 1;9(5):903-6. Epub 2007 Jan 31.

Chlorahololides A and B, two potent and selective blockers of the potassium channel isolated from Chloranthus holostegius.

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1
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, PRC.

Abstract

[structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifier (IK) K+ current, with an IC50 of 10.9 and 18.6 microM, respectively.

PMID:
17263543
DOI:
10.1021/ol0700759
[Indexed for MEDLINE]
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