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Immunol Cell Biol. 2007 Apr-May;85(3):182-8. Epub 2007 Jan 30.

Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens.

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Telethon Institute for Child Health Research, Centre for Child Health Research, School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.


It is widely accepted that tissue dendritic cells (DC) function as immune sentinels by alerting T cells to foreign antigen after delivering and presenting it in the draining lymph nodes. Over the last two decades, studies in animal models, particularly rodents, have demonstrated that respiratory tract DC are crucial for the adaptive immune response to inhaled antigen. Indeed, the fate of inhaled antigen is inextricably linked to the function of respiratory tract DC. In this review, we will discuss the characteristics of respiratory tract DC from mice and recent data that may help to explain their role in the fate of inhaled antigen.

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