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CMAJ. 2007 Jan 30;176(3):339-42.

Severe necrotizing pancreatitis following combined hepatitis A and B vaccination.

Author information

1
General Surgery Residency Program, University of Toronto, Toronto, Ont. eran.shlomo@gmail.com

Abstract

Necrotizing pancreatitis is a severe form of pancreatitis and is associated with substantial morbidity and mortality. We report a case of necrotizing pancreatitis that developed following combined hepatitis A and B vaccination. No other causes of pancreatitis could be determined. Although confirming the diagnosis is challenging, 3 main factors suggest a possible link to the vaccine: the chronology of the events, the patient's human leukocyte antigen genotype and the incongruent immune response to the vaccine components. This report serves to alert physicians to the possible development of necrotizing pancreatitis after vaccination.

PMID:
17261831
PMCID:
PMC1780095
DOI:
10.1503/cmaj.060360
[Indexed for MEDLINE]
Free PMC Article

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