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Stroke. 2007 Feb;38(2 Suppl):759-62.

Brain injury after intracerebral hemorrhage: the role of thrombin and iron.

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Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.


Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.

[Indexed for MEDLINE]

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