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Nat Neurosci. 2007 Mar;10(3):277-9. Epub 2007 Jan 28.

Direct activation of the ion channel TRPA1 by Ca2+.

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1
Klinik für Anaesthesiologie und operative Intensivmedizin, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, D-12200 Berlin, Germany.

Abstract

TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.

PMID:
17259981
DOI:
10.1038/nn1843
[Indexed for MEDLINE]
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