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Nat Rev Immunol. 2007 Feb;7(2):131-43.

Regulation of T-cell activation by the cytoskeleton.

Author information

1
Department of Immunology, Mayo Clinic College of Medicine, 200 First Street South West, Rochester, Minnesota 55905, USA.

Abstract

To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.

PMID:
17259969
DOI:
10.1038/nri2021
[Indexed for MEDLINE]

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