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Gastrointest Endosc. 2007 Feb;65(2):330-4.

Familial dysphagia and eosinophilia.

Author information

1
Division of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.

Abstract

BACKGROUND:

Recent reports suggest a familial predisposition to eosinophilic esophagitis (EE) and a link between Schatzki's rings and EE.

OBJECTIVE:

Our objective is to present our experience with 7 families with dysphagia and eosinophilia.

DESIGN:

Case series.

SETTING:

One-thousand-bed community-based teaching hospital.

PATIENTS:

Seventeen patients from 7 families with dysphagia and eosinophilia.

METHODS:

Direct clinical and endoscopic examination with review of radiologic and pathologic data.

RESULTS:

Twelve patients had EE alone, one had eosinophilic gastroenteritis (EG) alone, one had EE and EG, and 3 geriatric patients had Schatzki's rings (one with EG and peripheral eosinophilia [PE] and one with PE). EE spanned 2 generations in 4 families and involved 2 brothers in one family.

LIMITATIONS:

This was a case series.

CONCLUSION:

We propose a familial dysphagia syndrome characterized by eosinophilia in the form of EE, EG, or PE and Schatzki's rings in older generations.

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PMID:
17258999
DOI:
10.1016/j.gie.2006.07.021
[Indexed for MEDLINE]

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