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Am J Ophthalmol. 2007 Feb;143(2):344-6. Epub 2006 Sep 29.

Elevated serum homocysteine, low serum vitamin B12, folate, and age-related macular degeneration: the Blue Mountains Eye Study.

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1
Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia.

Abstract

PURPOSE:

To assess associations between increased serum homocysteine, low vitamin B12, low folate, and age-related macular degeneration (AMD).

DESIGN:

Population-based, cross-sectional analysis.

METHODS:

Serum homocysteine, vitamin B12, and folate were measured in 2,335 participants of the Blue Mountains Eye Study second survey. AMD detected from retinal photographs included atrophic or neovascular lesions.

RESULTS:

After adjusting for age, gender, and smoking in logistic regression models, homocysteine >15 micromol/l was associated with an increased likelihood of AMD in participants aged <75 years (odds ratio [OR] 3.21, 95% confidence interval [95% CI] 1.09 to 9.43). A similar association was found for vitamin B12 <125 pmol/l (OR 2.30, 95% CI 1.08 to 4.89) among all participants. In participants with homocysteine < or =15 micromol/l, low serum B12 was associated with nearly four-fold higher odds of AMD (OR 3.74, 95% CI 1.06 to 13.24). Folate was not statistically significantly associated with AMD.

CONCLUSIONS:

Increased homocysteine and low vitamin B12 were independently associated with an increased risk of AMD in this study population.

PMID:
17258528
DOI:
10.1016/j.ajo.2006.08.032
[Indexed for MEDLINE]
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