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FEBS Lett. 2007 Feb 20;581(4):658-62. Epub 2007 Jan 19.

Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0.

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Viral Silencing and Centromeric Instability team, Université de Lyon, Lyon, F-69003, France.


The ICP0 protein of herpes simplex virus type 1 (HSV-1) is a nuclear protein that possesses a well-characterized E3 ubiquitin ligase activity. This activity is responsible for the proteasomal-dependent degradation of several cellular proteins. This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells. It is also shown that the ICP0-induced CENP-B degradation occurs as efficiently in human and mouse cells. CENP-B is one of the major proteins of centromeres and its degradation is likely to contribute to the severe damage induced to centromeres by ICP0.

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