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Bioorg Med Chem Lett. 2007 Mar 15;17(6):1523-6. Epub 2007 Jan 13.

Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones.

Author information

1
Discovery Research, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, CA 92121, USA.

Abstract

A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent receptor modulating activities in the cotransfection assays.

PMID:
17257838
DOI:
10.1016/j.bmcl.2007.01.007
[Indexed for MEDLINE]

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