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Acc Chem Res. 2007 Apr;40(4):275-86. Epub 2007 Jan 26.

Organotrifluoroborates: protected boronic acids that expand the versatility of the Suzuki coupling reaction.

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1
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.

Abstract

Organotrifluoroborates represent an alternative to boronic acids, boronate esters, and organoboranes for use in Suzuki-Miyaura and other transition-metal-catalyzed cross-coupling reactions. The trifluoroborate moiety is stable toward numerous reagents that are often problematic for other boron species. Consequently, remote functional groups within the organotrifluoroborates can be manipulated, while retaining the valuable carbon-boron bond.

PMID:
17256882
DOI:
10.1021/ar050199q
[Indexed for MEDLINE]
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