Abstract
A new hydrogenated azaphilone Sch725680 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was achieved based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 64 microg/ml, respectively.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Aspergillus / chemistry*
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Aspergillus / metabolism
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Benzopyrans / chemistry*
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Candida albicans / drug effects
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Fermentation
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Saccharomyces cerevisiae / drug effects
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Spectrometry, Mass, Electrospray Ionization
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Benzopyrans
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Sch 725680