A new hydrogenated azaphilone Sch 725680 from Aspergillus sp

J Antibiot (Tokyo). 2006 Nov;59(11):720-3. doi: 10.1038/ja.2006.96.

Abstract

A new hydrogenated azaphilone Sch725680 (1) was isolated and identified from the culture of an Aspergillus sp. The structure elucidation of 1 was achieved based on extensive NMR spectroscopic analyses. Compound 1 showed inhibitory activity against Saccharomyces cerevisiae (PM503) and Candida albicans (C43) with MICs of 8 and 64 microg/ml, respectively.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry*
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Aspergillus / chemistry*
  • Aspergillus / metabolism
  • Benzopyrans / chemistry*
  • Benzopyrans / isolation & purification
  • Benzopyrans / pharmacology
  • Candida albicans / drug effects
  • Fermentation
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Saccharomyces cerevisiae / drug effects
  • Spectrometry, Mass, Electrospray Ionization
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Benzopyrans
  • Sch 725680