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J Antibiot (Tokyo). 2006 Nov;59(11):698-703.

Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.

Author information

1
Department of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.

Abstract

In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.

PMID:
17256468
DOI:
10.1038/ja.2006.93
[Indexed for MEDLINE]

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