Abstract
The theory that the spatial organization of cell fate is orchestrated by gradients of diffusing molecules was a major contribution to 20th century developmental biology. Although the existence of morphogens is no longer in doubt, studies on the formation and function of their gradients have yielded far more puzzles than answers. On close inspection, every morphogen gradient seems to use a rich array of regulatory mechanisms, suggesting that the tasks carried out by such systems are far more extensive than previously thought.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Body Patterning / physiology*
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Diffusion
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Embryo, Mammalian / cytology
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Embryo, Mammalian / metabolism
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Gene Expression Regulation, Developmental / physiology*
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Humans
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Intercellular Signaling Peptides and Proteins / genetics
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Intercellular Signaling Peptides and Proteins / metabolism*
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Models, Biological
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Morphogenesis / physiology*
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Signal Transduction / physiology*
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Systems Biology / methods
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Systems Biology / trends*
Substances
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Intercellular Signaling Peptides and Proteins