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Cell. 2007 Jan 26;128(2):225-31.

Genetic screening for signal transduction in the era of network biology.

Author information

1
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02175, USA.

Abstract

In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.

PMID:
17254958
DOI:
10.1016/j.cell.2007.01.007
[Indexed for MEDLINE]
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