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Curr Opin Neurobiol. 2007 Feb;17(1):15-21. Epub 2007 Jan 24.

Netrin signaling leading to directed growth cone steering.

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Department of Molecular, Cellular and Developmental Biology and Cell Biology, Yale University, 219 Prospect Street, Kline Biology Tower-232, New Haven, CT 06520, USA.


In the developing nervous system, nerve cells and axons respond to various attractive and repulsive guidance cues while traveling to their final destination. Netrins are bifunctional guidance cues that attract several classes of axons but repel others. The response of an axon to netrins is dictated by the composition of netrin receptors on the cell surface and the internal state of the growth cone. Recent analyses have identified several signal transduction pathways that contribute to netrin-mediated guidance. A model emerges in which tyrosine phosphorylation, phosphatidylinositol signaling and regulation by Rho GTPases act in concert to trigger extension of axons and turning of growth cones in response to Netrin1.

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