Abstract
One new erythrinian alkaloid derivative, (+)-11alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of 1H, 13C, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Anti-Anxiety Agents / chemistry
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Anti-Anxiety Agents / isolation & purification*
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Anti-Anxiety Agents / pharmacology
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Brazil
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Erythrina / chemistry*
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Flowers / chemistry
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Male
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Mice
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
Substances
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(+)-11alpha-hydroxyerythravine
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(+)-alpha-hydroxyerysotrine
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(+)-erythravine
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Alkaloids
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Anti-Anxiety Agents
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Heterocyclic Compounds, 4 or More Rings