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Biochimie. 1991 Dec;73(12):1493-500.

Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycin.

Author information

1
Section of Biochemistry, Brown University, Providence, RI 02912.

Abstract

Strains containing a series of restrictive and non-restrictive mutations in ribosomal protein S12 have been transformed with plasmids carrying the rrnB operon with mutations at positions 1409 and 1491 in 16S rRNA. The effects of the double-mutant constructs have been measured by growth rate, paromomycin and streptomycin sensitivity, resistance and dependence. The results demonstrate a functional interaction between the 1409-1491 region of rRNA and ribosomal protein S12.

PMID:
1725261
DOI:
10.1016/0300-9084(91)90183-2
[Indexed for MEDLINE]

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