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Eur J Clin Nutr. 2007 Sep;61(9):1086-93. Epub 2007 Jan 24.

Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.

Author information

1
Graduate School of Human Health Science, Siebold University of Nagasaki, Nagasaki, Japan.

Abstract

OBJECTIVES:

To estimate the suppressive effect of partially hydrolyzed guar gum (PHGG) on transitory diarrhea induced by ingestion of a sufficient amount of maltitol or lactitol in female subjects.

DESIGN:

The first, the minimal dose level of maltitol and lactitol that would induce transitory diarrhea was estimated separately for each subject. Individual subject was administered a dose that increased by 5 g stepwise from 10 to 45 g until diarrhea was experienced. Thereafter, the suppressive effect on diarrhea was observed after each subject ingested a mixture of 5 g of PHGG and the minimal dose level of maltitol or lactitol.

SETTING:

Laboratory of Public Health Nutrition, Department of Nutrition and Health Sciences, Siebold University of Nagasaki.

SUBJECTS:

Thirty-four normal female subjects (21.3+/-0.9 years; 49.5+/-5.3 kg).

MAIN OUTCOME MEASUREMENT:

Incidence of diarrhea caused by the ingestion of maltitol or lactitol and the ratio of suppression achieved by adding PHGG for diarrhea.

RESULTS:

The ingestion of amounts up to 45 g of maltitol, diarrhea caused in 29 of 34 subjects (85.3%), whereas the ingestion of lactitol caused diarrhea in 100%. The diarrhea owing to maltitol was improved in 10 of 28 subjects by the addition of 5 g of PHGG to minimal dose-induced diarrhea, and that owing to lactitol was in seven of 19 subjects. Adding 10 g of PHGG strongly suppressed the diarrhea caused by maltitol, and the cumulative ratio was 82.1% (23/28).

CONCLUSION:

The transitory diarrhea caused by the ingestion of maltitol or lactitol was clearly suppressed by the addition of PHGG. These results strongly suggest that diarrhea caused by the ingestion of a sufficient amount of non-digestible sugar substitute can be suppressed by the addition of dietary fiber.

PMID:
17251924
DOI:
10.1038/sj.ejcn.1602623
[Indexed for MEDLINE]

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