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Org Lett. 2007 Feb 1;9(3):385-8.

Asymmetric total synthesis of nigerone.

Author information

1
Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.

Abstract

[reaction: see text] An enantioselective synthesis of the chiral bisnaphthopyrone natural product nigerone is reported. The key step was an eight-step isomerization process to form the final natural product. The isomerization precursor was constructed via asymmetric oxidative biaryl coupling of an advanced intermediate with a 1,5-diaza-cis-decalin copper catalyst.

PMID:
17249768
DOI:
10.1021/ol062468y
[Indexed for MEDLINE]
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