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Nat Rev Mol Cell Biol. 2007 Feb;8(2):161-7.

Microtubule-organizing centres: a re-evaluation.

Author information

1
Department of Biological Sciences, Stanford University, CA 94305, USA.

Abstract

The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires gamma-tubulin. Here we discuss recent evidence indicating that gamma-tubulin-dependent formation of new microtubules is not restricted to conventional microtubule-organizing centres. These findings suggest that the spatio-temporal control of microtubule nucleation is more complex than previously thought, leading us to a re-evaluation of the concept of the microtubule-organizing center.

PMID:
17245416
DOI:
10.1038/nrm2100
[Indexed for MEDLINE]

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