Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2007 Feb;8(2):139-48.

Post-translational modifications regulate the ticking of the circadian clock.

Author information

1
Center for Children, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA. Monica.Gallego@hci.utah.edu

Abstract

Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during late afternoon seminars. Our internal clocks control these and many more workings of the body, and disruptions of the circadian clocks predispose individuals to depression, obesity and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them.

PMID:
17245414
DOI:
10.1038/nrm2106
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center