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[Genetics and epigenetics in autism].

[Article in Japanese]

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Department of Embryology, Institute for Developmental Research, Aichi Human Service Center, 713-8 Kagiya-cho, Kasugai, 480-0392 Japan.


Autism is a behaviorally defined syndrome characterized by impaired social interaction and communication, and restricted, stereotyped interests and behaviors. Several lines of evidence support the contention that genetic factors are a large component to autism etiology. However, in spite of vigorous genetic studies, no single causative or susceptibility gene common in autism has been identified. Thus multiple susceptibility genes in interaction are considered to account for the disorder. Furthermore, environmental risk factors can accelerate the autism development of. Recent advances in understanding the epigenetic regulation may shed light on the interaction among multiple genetic factors and environmental factors.

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