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Resuscitation. 2007 Mar;72(3):353-63. Epub 2007 Jan 18.

Room air resuscitation of the depressed newborn: a systematic review and meta-analysis.

Author information

1
Department of Medicine, University of Calgary, Partnership for Research and Education in Mothers and Infants (PREMI) Institute, Calgary Health Region, Calgary, Alberta, Canada. jack.rabi@calgaryhealthregion.ca

Abstract

Understanding of the potential dangers of hyperoxia in the newborn is growing. Several studies have examined the use of room air for the resuscitation of newborns.

OBJECTIVE:

To assess the effects of room air resuscitation versus 100% oxygen resuscitation on mortality at 1 week and 1 month in asphyxiated newborn infants.

STUDY DESIGN:

Systematic review and meta-analysis of seven randomized and quasi-randomised controlled trials comparing room air and 100% oxygen resuscitation of newborn infants.

RESULTS:

Compared to the 100% oxygen resuscitation group, neonates in the room air resuscitation group had a lower mortality both in the first week of life (odds ratio 0.70, 95% CI 0.50, 0.98) and at 1 month and beyond (odds ratio 0.63, 95% CI 0.42, 0.94). The incidence of severe hypoxic ischemic encephalopathy (Stage II and Stage III) was similar between the two groups.

CONCLUSION:

This meta-analysis supports the hypothesis that room air is superior to 100% oxygen as the initial choice for resuscitating clinically depressed newborns as it may result in a lower mortality rate. However, adequately powered studies of long-term neurodevelopmental outcomes are not yet available.

[Indexed for MEDLINE]

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