Format

Send to

Choose Destination
Vaccine. 2007 Feb 26;25(10):1727-34. Epub 2006 Nov 27.

Neurologic disease associated with 17D-204 yellow fever vaccination: a report of 15 cases.

Author information

1
1401 Rockville Pike, HFM-220, Rockville, MD 20852, USA. ann.mcmahon@fda.gov

Abstract

Yellow fever (YF), can be prevented by an attenuated vaccine (YEL). We reviewed neurologic adverse events (AE) following YEL that were reported to the national Vaccine Adverse Events Reporting System (VAERS). VAERS is a passive reporting system with inherent limitations for causality assessment. Based on defined criteria, five cases of encephalitis were classified as 'definitely' and one of acute disseminated encephalomyelitis (ADEM) as 'probably' caused by YEL. Six cases of Guillain-Barre Syndrome (GBS), one of encephalitis, and two of ADEM, were classified as 'suspect' vaccine-associated disease. Laboratory and epidemiological evidence suggests that YEL caused encephalitis. Additional studies will be required to confirm whether YEL can rarely result in GBS and/or ADEM.

PMID:
17240001
DOI:
10.1016/j.vaccine.2006.11.027
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center