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PLoS Pathog. 2007 Jan;3(1):e4.

In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions.

Author information

1
Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California, United States of America.

Abstract

In the prevailing model of HIV-1 trans-infection, dendritic cells (DCs) capture and internalize intact virions and transfer these virions to interacting T cells at the virological synapse. Here, we show that HIV-1 virions transmitted in trans from in vitro derived DCs to T cells principally originate from the surface of DCs. Selective neutralization of surface-bound virions abrogated trans-infection by monocyte-derived DCs and CD34-derived Langerhans cells. Under conditions mimicking antigen recognition by the interacting T cells, most transferred virions still derived from the cell surface, although a few were transferred from an internal compartment. Our findings suggest that attachment inhibitors could neutralize trans-infection of T cells by DCs in vivo.

PMID:
17238285
PMCID:
PMC1779297
DOI:
10.1371/journal.ppat.0030004
[Indexed for MEDLINE]
Free PMC Article
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