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Nat Chem Biol. 2007 Mar;3(3):154-5. Epub 2007 Jan 21.

Small-molecule regulation of zebrafish gene expression.

Author information

1
Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Center for Clinical Sciences Research, Room 3155, Stanford, California 94305, USA.

Abstract

The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.

PMID:
17237798
DOI:
10.1038/nchembio858
[Indexed for MEDLINE]
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