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EMBO Rep. 2007 Feb;8(2):165-72. Epub 2007 Jan 19.

MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly.

Author information

1
European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany.

Abstract

The metazoan nuclear envelope (NE) breaks down and re-forms during each cell cycle. Nuclear pore complexes (NPCs), which allow nucleocytoplasmic transport during interphase, assemble into the re-forming NE at the end of mitosis. Using in vitro NE assembly, we show that the vertebrate homologue of MEL-28 (maternal effect lethal), a recently discovered NE component in Caenorhabditis elegans, functions in postmitotic NPC assembly. MEL-28 interacts with the Nup107-160 complex (Nup for nucleoporin), an important building block of the NPC, and is essential for the recruitment of the Nup107-160 complex to chromatin. We suggest that MEL-28 acts as a seeding point for NPC assembly.

PMID:
17235358
PMCID:
PMC1796766
DOI:
10.1038/sj.embor.7400889
[Indexed for MEDLINE]
Free PMC Article

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